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We further performed doxycycline-inducible expression of oxygen-dependent NADPH oxidase (NOX) in the cytosol (TPNOX) or mitochondria (mitoTPNOX) to deplete compartmentalized NADPH, as described previously 30 , and tested the cellular sensitivity to glucose starvation (Extended Data Fig

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The following comparison outlines how common non-surgical options differ: MIC injections occupy a lower-cost, lower-evidence tier compared to FDA-approved treatments

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