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years to full benefit GHK-Cu copper peptide Direct fibroblast activation Collagen and elastin synthesis from day one Antioxidant and anti-inflammatory Well-tolerated by all skin types No increased sun sensitivity Safe for sensitive and post-procedure skin Visible improvement typically within 48 weeks The head-to-head data A 2009 split-face study published in the Journal of Cosmetic Dermatology compared a GHK-Cu cream against a retinol cream over 12 weeks