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10.1016/j.heliyon.2023.e21225 11

Can be part of a plan for fat loss, muscle growth, and healthy aging

In order to maintain a steady supply of glucose, glucagon strongly stimulates glycogenolysis and suppresses glycogenesis in the liver [28, 29]

These approaches included anti-IGF-1R monoclonal antibodies (mAbs), IGF-1R tyrosine kinase inhibitors (TKIs), IGF-1/2 blocking mAbs, IGF ligand-TRAPs, recombinant IGFBPs and pregnancy-associated plasma protein-A (PAPP-A) inhibition [54,55]