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Decreases in tissue concentrations of SAM, resulting from depletion of the folate stores, induce inhibition of the transsulfuration reactions (Fig

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Epigenetic mechanisms include DNA methylation, histone modification, and the presence of small non-coding ribonucleic acid (RNA) molecules such as micro-RNA (miRNA) that regulate the post-transcriptional expression of target genes in the oncogenic process [29]

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GSSG is the cellular intermediate the cycle returns to GSH through the action of glutathione reductase

REFERNCIAS BIBLIOGRFICAS MINISTRIO DA SADE