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The detoxification reactions comprise the first four steps of mercapturic acid synthesis, [19] with the conjugation to GSH serving to make the substrates more soluble and allowing them to be removed from the cell by transporters such as multidrug resistance-associated protein 1 (MRP1)

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This review focuses on the expression, regulation and evolution of GPX3 in non-neoplastic diseases, assesses its potential as a prognostic and diagnostic biomarker and explores new therapeutic avenues targeting GPX3