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Overall, experience from the oncology field suggests that amino acid metabolism intervention is more likely to be implemented through well-defined clinical development strategies, including monotherapy or combination therapy, dose escalation, safety monitoring, and immune pharmacodynamic endpoints, and may provide a useful framework for trial design and stratification in immune-mediated diseases
In some patients resins may increase hepatic VLDL formation, resulting in increased serum TG concentration
Authors:Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA, Journal:J Biol Chem PubMed ID:17690097 Bcl-2 protects cells against mitochondrial oxidative stress and subsequent apoptosis