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Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides

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Our study found that PPAR expression is significantly reduced in OA cartilage compared to normal cartilage 35

Further potential alterations in the excitation-contraction coupling proteins, supplement consumption has been proposed to change the high-energy phosphate turnover and phosphorus metabolites in the skeletal muscle ( reduces the cost of high-energy phosphates in the generation of skeletal muscle contraction (74)