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Exenatide once weekly versus placebo in parkinson's disease: a randomised, double-blind, placebo-controlled trial

SM: Advisory boards: AstraZeneca, Boehringer Ingelheim, Intarcia Therapeutics, Novo Nordisk, Sanofi, Abbott Lab, Bayer, Amgen

GLP-1 is one of the key hormonal components of the intestinal traffic control mechanism known as the ileal brake, which regulates the rate of nutrient transit and absorption

They work by scavenging free radicals and reducing oxidative stress, thereby mitigating the risk of conditions such as heart disease, cancer, and neurodegenerative disorders

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Tirzepatide vs Semaglutide for Metabolic Research: What the Head-to-Head Evidence Shows The most definitive head-to-head data comes from SURMOUNT-5, published in the New England Journal of Medicine in 2025