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Vinciguerra et al., 2020

Gong Y, et al

IRE1 kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates

Pharmacotherapy: semaglutide treatment GLP-1 Receptor Agonists (GLP-1 RAs) are a group of medications used to treat type 2 diabetes and obesity by mimicking the incretin hormone GLP-1, thereby promoting blood glucose reduction and weight loss, along with providing added advantages such as lowering cardiovascular and renal risk

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Adrenal tumours typically require surgical adrenalectomy, whilst ectopic ACTH-secreting tumours necessitate identification and removal of the primary malignancy when feasible