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FOR SOME PATIENTS INCREASING TO 10MG, 12.5MG OR 15MG DOSES MAY BE NECESSARY

After cardiopulmonary bypass, intermittent IV paracetamol reduced 48-hour morphine exposure by approximately 79% without worsening pain control, supporting opioid-sparing with rapid rescue (68)

Never inject into areas without sufficient subcutaneous fat, such as very lean abdominal areas or over bone

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Key points The rs10830963 single-nucleotide polymorphism (SNP) in the MTNR1B locus is associated with increased fasting plasma glucose levels and impaired insulin secretion, as well as increased risk of type 2 diabetes mellitus (T2DM) and gestational diabetes mellitus

It is one of several agents in the broader GLP-1 receptor agonist class, which now dominates the metabolic and weight-loss landscape