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Doses above 3 mg per day lack additional evidence of benefit and are not generally recommended

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In integrative medicine, its viewed as a targeted peptide messenger that may support the bodys own healing responses, especially in the digestive tract, joints, and soft tissues

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Senolytic Peptide FOXO4-DRI Selectively Removes Senescent Cells From in vitro Expanded Human Chondrocytes Huang Y, He Y, Makarcyzk MJ, Lin H Frontiers in Bioengineering and Biotechnology (2021) This study demonstrated that FOXO4-DRI selectively removes senescent cells from human chondrocyte cultures expanded in vitro, providing direct evidence of the peptide's senolytic activity in human cells relevant to joint and cartilage aging

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