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Mn uptake via voltage-gated calcium channels in dopaminergic neurons has also been reported (Dui et al., 2013), but again at high Mn concentrations
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The context-dependent regulation of NRF2 creates therapeutic dilemmas: While NRF2 activation shows promise for treating neurodegenerative diseases by enhancing antioxidant defenses, its inhibition may be required in cancers where NRF2 hyperactivation promotes tumor survival and drug resistance
coli as a nutritional source were used as a food source, and starvationrefeeding experiments were performed with and without additional L-carnitine supplementation
