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Counterions (19 Na + ions for truncated Ab Pcob and 58 Na + ions for full-length Ab DPcob) were added to neutralise the system

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Group 1 had eGFR 60 mL/min, no established coronary artery disease (CAD), no previous cardiovascular events (stroke/myocardial infarction), and no heart failure (HF), ( n = 76,302)

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Usually worst during dose increases

Alternative poly(A) signals are employed and in some variants, there are internal deletions in some of the domains