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10.1186/s12891-024-07411-3 187 YueweiS.IsabelA.DeC.MjM.AfM.MT.et al (2014)

One factor that determines the rate of success is how quickly you tolerate the medicine as the dose is increased

This divergence suggests that the protective effects identified in the pathway analysis may involve mechanisms beyond genetic proxies, such as metabolic conditions (e.g., insulin resistance, inflammation), cellular states (e.g., energy stress, mitochondrial function), and environmental factors (e.g., antiviral effects, microbiota composition changes)

Moreover, another study reported that GSTM2 binds to ASK1 15

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