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Prolonged IGF-1 elevation may interfere with insulin signaling pathways, resulting in glucose metabolism disruption and increased diabetes risk. Clemmons, The Journal of Clinical Endocrinology & Metabolism Cell Overproliferation and Cancer Concerns IGF-1 promotes cell growth and replication , which is great for musclebut not ideal in individuals with: A history of cancer A family history of hormone-sensitive tumors Undiagnosed growths or cysts IGF-1 is considered mitogenic , meaning it encourages cell division

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Insulin helps control blood sugar levels by helping cells absorb glucose for energy

The statistics back up that perception

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reported that HPE led to suppression of the body weight reduction through its ability to prevent atrophy of adipose tissue and skeletal muscle and lowering oxidative cell death