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Moreover, oxidative stress-induced epigenetic alterations, including mutations and inactivation of the ARID1A gene, may lead to chromatin remodeling and dysregulated gene expression, accelerating disease advancement

SOUL study is an ongoing CVOT trial with oral semaglutide to look for CV benefits where more than 9500 patients are enrolled

The injection is minimally invasive and generally well-tolerated

Human safety is not established because large human trials have not been completed

Although the relevance of these mechanisms in MMNST remains to be fully elucidated, we hypothesize that, in this case, anlotinib contributed to durable disease control not only through its established antiangiogenic and antiproliferative actions but also by promoting vascular normalization, reshaping the immune microenvironment, and potentially modulating the PRKAR1A/ERK axis

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