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Specifically, this action occurred via oxidation of the Src kinase Src42, and supported results from a previous study in which mitochondrial ROS (mtROS) was produced downstream of Ca 2+ bursts following wounding 118

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Dose-Pause and Discontinuation Patterns Phase 1/2 protocols allowed dose-interruption for severe injection-site reactions, IGF-1 elevations above protocol thresholds, and protocol-defined laboratory abnormalities