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This effect was mediated by the upregulation of PKA/CREB signaling and the downregulation of the Notch/Hes-1 pathway, leading to enhanced peroxisome proliferator-activated receptor coactivator 1 expression, thus improving gentamicin-induced renal injury in rats (115)

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Nrf2 plays a critical role in mitigating lipid peroxidation and ferroptosis

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a pilot study

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