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Also, there are a few factors that can affect the cost of the treatment

The drugs will be reimbursed at 65 per cent, though in practice the vast majority of eligible patients benefit from 100 per cent coverage due to comorbidities, she added.

Retatrutide can plausibly cause heartburn-type symptoms because its GLP-1 receptor activity slows gastric emptying, increasing intra-gastric pressure and the likelihood of acid reflux

These medications are still relatively new in Japan, and not all doctors are familiar with GLP-1 treatments or able to prescribe them

[7] [11] In a Phase 2 randomised controlled trial published in The New England Journal of Medicine (Jastreboff et al., 2023), retatrutide demonstrated substantial reductions in body weight over 48 weeks

This finding not only further explains the mechanism by which AA-CDs inhibit chondrocyte ferroptosis but also provides a new direction for the research on THM-CDs