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Gastrointestinal tolerance : Some patients experience significant nausea or other side effects that limit their ability to escalate doses as scheduled

West S, Aveyard P, Scragg J, et al

Patients with Renal Impairment Dulaglutide systemic exposure was increased by 20, 28, 14 and 12% for mild, moderate, severe, and ESRD renal impairment sub-groups, respectively, compared to subjects with normal renal function

Figure 4A showed a high-risk prediction with a final SHAP value of 0.755, mainly due to GGT (+0.25), LMWH use (+0.04), and ALT (+0.04)

Instead, calcitonin levels remained at the lower end of the normal range

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