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OCTN cation transporters in health and disease: role as drug targets and assay development

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Conditions necessitating frequent transfusions, such as myelodysplastic syndromes (MDS), -thalassemia, and sickle cell disease (SCD), can result in transfusional iron overload [31,32,33,34,35,36,37]

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332 Response analysis of PDAC organoids to five commonly used chemotherapeutics (5-FU, irinotecan, oxaliplatin, gemcitabine and paclitaxel) showed that one-third of PDOs were resistant to all five drugs, and half of the patients who provided these PDOs were highly sensitive to targeted drugs