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In current metabolic peptide research, this refers to compounds that activate GLP-1, GIP, and glucagon receptors retatrutide being the leading example

Last, but not least, it has been demonstrated that such drugs can raise energy expenditure, or the number of calories the body burns while at rest

Considering results from all patients exposed to GLP-1 agonist use, the medication is safe, and a NNH as high as 1000 can be rejected

Nature Reviews Drug Discovery