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No Titration Requirement: Many GLP-1 therapies require careful titration to mitigate adverse gastrointestinal effects, which can complicate treatment

A bloodbrain barrier (BBB) dysfunction associated with BD is observed, also linked to gut microbiota, substance abuse and insulin resistance, all altering neuronal plasticity [140, 141]

Patients who inject semaglutide in the morning often report feeling fuller throughout the day and eating smaller breakfasts, while those who prefer evening injections frequently experience reduced nighttime snacking and improved sleep-related hunger control

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Endocrine 91 (1), 23 (2026).