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Rapid fat reduction decreases structural support beneath the skin, leading to facial volume loss and skin laxity, particularly in older patients or those with reduced collagen production

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As demand and options are shaped by GLP-1 RAs, a growing need for support is becoming evident

They may be more noticeable if the medication is cold, the alcohol has not fully dried, the needle passes through a tiny surface blood vessel, or the area is more sensitive than usual that day

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The clinical significance of this effect on supplement uptake has not been directly studied