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-SMA, 5-GCTGGTGATGATGCTCCCA-3 and 5-GCCCATTCCAACCATTACTCC-3
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Collectively, our data identify a series of tesaglitazar targets in the hypothalamus and show that the GLP-1RA/tesaglitazar conjugate improves body weight, food intake and glucose metabolism with superior efficacy relative to treatment with the GLP-1RA, tesaglitazar or the fixed dose combination of GLP-1RA and tesaglitazar
2021;44:S1124
The adoption of emerging strategies, including rational surface engineering (mucoadhesive ligands, receptor-targeting motifs), protease- and acid-resistant peptide motifs, hybrid proteinpolysaccharide assemblies, and stimuli-responsive designs, will help address these limitations
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