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Physiol Behav 206:232242 Bruns VN, Tressler EH, Vendruscolo LF et al (2024) IUPHAR review-Glucagon-like peptide-1 (GLP-1) and substance use disorders: an emerging pharmacotherapeutic target

Originally developed to treat HIV-associated lipodystrophy, tesamorelin has shown promise in reducing abdominal fat and improving metabolic health in individuals with this condition

Circulating MOTS-c declines with age and tracks with insulin resistance, making it both a potential longevity biomarker and a therapeutic target

The combination group showed 1.3 kg greater fat mass reduction measured via DEXA scan, though the difference did not reach statistical significance (p=0.08)