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The Triple Agonist Mechanism and Weight Loss Huberman described retatrutide as a triple agonist of the GLP-1, glucagon, and GIP receptors, and noted that it is sometimes referred to as "GLP-3." He made a striking claim about the weight loss data: "In a phase three clinical trial in humans, it caused up to one-third loss of body weight

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A balanced approach: supplements may support overall metabolic health and digestion, but they are not replacements for evidence-based GLP-1 receptor therapy

In-gel digestion of 20 g of the protein lysates was performed for the LC-MS-based proteomics analyses, as described previously [31]

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PubMed Central , British Journal of Clinical Pharmacology , vol