After 4 weeks, increase to 5 mg once weekly
Patients with type 1 diabetes, kidney cancer, or kidney failure (eGFR 30 mg/g) [19]
Key Structural Differences# Head-to-Head: LEAD-6 Trial# The LEAD-6 trial (Buse et al., Lancet 2009) directly compared liraglutide 1.8 mg once daily with exenatide 10 mcg twice daily in 464 adults with type 2 diabetes inadequately controlled on metformin, sulfonylurea, or both over 26 weeks: Liraglutide was statistically superior for glycemic control and demonstrated better tolerability, with less persistent nausea and fewer hypoglycemia events
Skin samples were fixed with 4% paraformaldehyde, embedded in paraffin, and sectioned for H&E, Masson, and immunohistochemical staining
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Plaintiffs argue this is insufficient
