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In vehicle-treated rats, fentanyl elicited (1) an increase in TFL, (2) decreases in pH, pO 2 and sO 2 and increases in pCO 2 (all indicative of ventilatory depression), (3) an increase in Alveolar-arterial gradient (indicative of a mismatch in ventilation-perfusion in the lungs), and (4) changes in ventilatory parameters such as a reduction in tidal volume, that were indicative of pronounced ventilatory depression

The protocols that work are the ones where every step is documented, timed, and executed identically across all vials

Rosa AR, Singh N, Whitaker E, de Brito M, Lewis AM, Vieta E et al

Insulin resistance the link between T2DM and CVD: basic mechanisms and clinical implications

10.1016/j.intimp.2021.108175 52 XuZ.ZhangQ.DingC.WenF.SunF.LiuY.et al (2023)

In the screen, we compared the effect that electrophiles (at 10 M) had on the viability of senescence and normal cells, identifying 72 candidates with senolytic activity (Fig