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A total of 18 samples were quantitatively compared using tandem mass tag (TMT)-based mass spectrometry (MS) proteomics (Fig
This is a normal physiologic response, not treatment failure
Given that cuproptosis preferentially targets OXPHOS-dependent cells by disrupting TCA cycle enzymes and Fe-S cluster integrity, 167,213 it remains an open question whether GSH-dependent Fe-S cluster biogenesis similarly licenses susceptibility to cuproptosis
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[PubMed: 16935845] 198
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