177 In vivo, mitochondrial dynamics-related factor Parkin was significantly reduced in the substantia nigra of a mice fed a high-fat diet and a diabetic mice, leading to the accumulation of Parkin-interacting substrate and the reduction of PGC-1
The average conservation scores for the selected regions in 5' NCR, CORE, E1, NS5B are 96%, 91%, 80% and 80% respectively suggesting that a region which can serve to discriminate genotypes tends to be modestly conserved if not the least conserved
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