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Furthermore, probiotics help maintain immunological equilibrium by attenuating pathological inflammation through the inhibition of pro-inflammatory cytokine signaling and suppression of the nuclear factor-B (NF-B) pathway (253)

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The pathogenic characteristics of OA include synovitis, chondrocyte death, deterioration of the extracellular matrix (ECM), subchondral osteosclerosis, and osteophyte formation [4], resulting in elevated incidence and disability rates [5]

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These therapies are generally well tolerated when monitored, but possible effects include water retention or swelling, joint or nerve discomfort, irritation at the injection site, and shifts in blood sugar if growth hormone runs too high

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