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Research Overview
This disrupts the structural integrity of the intestinal epithelial barrier, reduces the expression of tight junction proteins (such as occludin, claudin and ZO-1) and increases intestinal barrier permeability 51
Data availability Source data are published as an accompanying file
It was developed as a more stable and potent analog of GHRP-6, designed to interact with the ghrelin receptor (GHS-R1a).[2] Once it binds to GHS-R1a receptors (found in both the hypothalamus and pituitary gland), hexarelin activates phospholipase C (PLC) and inositol triphosphate (IP3) signaling pathways
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