Substantial and sustained weight loss, even in individuals without diabetes
If you have side effects that dont seem to be getting better and you arent losing weight, discuss with your doctor whether Wegovy is the right treatment for you going forward
Secondly, the role of metformin that has received the most attention is its effect on tumor tissue, not only in terms of treatment, but also in terms of prevention (Coyle et al., 2016
These mechanisms not only improve glycemic control for individuals with diabetes but also provide a pathway for weight loss, making them appealing for those seeking to manage obesity
Unlike semaglutide, tirzepatide targets two hormone receptors: GLP-1 and GIP
As of 2025, retatrutide has not been granted marketing authorisation by the MHRA or EMA and is not available through the NHS or licensed UK private prescribers