For instance, Chiu et al
The most unusual expansion comprises more than 50 predicted genes with similarity to glutathione synthetase enzymes [12]: almost all eukaryotes possess only a single glutathione synthetase gene
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ROS activates p38 and c-Jun N-terminal kinase (JNK), and subsequently interferes with insulin signaling by increasing serine phosphorylation of insulin receptor substrate 1 (IRS-1) at specific sites, ultimately leading to insulin resistance
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