Up to 40% of Americans have suboptimal B12 levels, especially those over 40 or those taking certain common medications
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Constipation is less dose-dependent and can persist, making it a more durable reason for discontinuation in patient reports. Sulfur burps reflect food sitting longer in a slowed stomach. Fatigue ranks second only to nausea in patient forums, although much of it tracks the calorie deficit rather than tirzepatide itself. Fried or fatty foods, coffee, meat, and alcohol can also become less appealing
Overdosing can irritate the gastrointestinal tract, causing bloating or abdominal cramping
But the benefits go beyond just energy
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