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Abbreviations AKT: Serine/threonine-protein kinase BC: Betweenness centrality BP: Biological process CAT: Catalase CC: Cellular component COX: Cyclo-oxygenase DAVID: Database for annotation, visualization, and integrated discovery DC: Degree centrality DEGs: Differentially expressed genes DMARDs: Disease-modifying anti-rheumatic medications DME: Drynaria quercifolia methanol rhizome extract FCA: Freunds complete adjuvant GAPDH: Glyceraldehyde-3-phosphate dehydrogenase GEO: Gene expression omnibus GO: Gene ontology GSH: Reduced glutathione H-C-T-P: Herb-compound-target-pathway IK: Inhibitor of kappa beta IL-6: Interleukin-6 KEGG: Kyoto encyclopaedia of genes and genomes MD: Molecular dynamics MDA: Malondialdehyde MF: Molecular function NSAIDs: Non-steroidal antirheumatic drugs OMIM: Online Mendelian inheritance in man OPLS: Optimized potentials for liquid simulations PDB: Protein data bank PPARA: Peroxisome proliferator activated receptor alpha PPARG: Peroxisome proliferator activated receptor gamma PPI: Protein-protein interaction RA: Rheumatoid arthritis RA-FLS: RA fibroblast-like synoviocyte RASF: RA synovial fibroblast RMSD: Root mean square deviation RMSF: Root mean square fluctuations ROS: Reactive oxygen species SDF: Structure data file SEA: Similarity ensemble approach SMILE: Simplified molecular-input line-entry system SOD: Superoxide dismutase STP: Swiss target prediction TIP3P: Intermolecular interaction potential 3 points TNF: Tumor necrosis factor References Medzhitov, R

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Besides, HO-1 also has an important effect in novel programmed cell death such as pyroptosis and ferroptosis, thereby playing a protective role against diabetes

This can kill off beneficial bacteria from your hands-to-mouth or on your skin that directly affect your gut health and urinary tract health