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Distinctive Symptoms: Sharp, severe pain during bowel movements Pain lasting several minutes to hours after Bright red blood on toilet paper or stool Visible crack in the skin around the anus Muscle spasms in the anal sphincter What Distinguishes Fissures from Hemorrhoids: While both can cause bleeding, anal fissures cause much more intense, lingering pain

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*Correspondence: Marawan A

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Pimentel EF and their group (Pimentel et al., 2024) employed resonance mass spectrometry to analyze seed hulls, noting that PCs enhanced fibroblast functionality and migration, and increased the levels of vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF)

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