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Methionine: 0.1 to 1 mM in cell culture, 100 to 500 mg per kg in animal models

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Synergistic inhibitory effect of combination therapy on HSC proliferation Another clinical study showed that the -AR antagonist prazosin and the -AR antagonist propranolol individually inhibited HSC proliferation, but their combination led to a more pronounced inhibitory effect, suggesting a synergistic action in suppressing HSC proliferation 70

Hence, glutathione treatment reduces melanin production by the body, which lightens the skin