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Proc Natl Acad Sci USA 85:66226626

(B) Representative 3-day post imbibition photos of cat2 homozygous mutants, the T2-11-35S::CAT2-2xHA/Col-0 (CAT2 OE) line (line 11) and wild type (Col-0) plants grown on untreated LMS-1 and antioxidant treated LMS-1

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The formulations or compositions disclosed herein alternatively encompass an otoprotectant agent in addition to the at least one active agent and/or excipients, including but not limited to such as antioxidants, alpha lipoic acid, calcium, fosfomycin or iron chelators, to counteract potential ototoxic effects that arise from the use of specific therapeutic agents or excipients, diluents, or carriers