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Very few studies included older participants

Understanding the tumor immune microenvironment (TIME) for effective therapy

Compound 3 (VCT220) showed improved oral PK versus PF-06882961 (danuglipron), with ~21-fold higher Cmax and ~5.8-fold higher AUC in rats at 10 mg/kg, and 51% oral bioavailability in monkeys versus 8%

Tuffaha SH, Singh P, Budihardjo JD, et al

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JAMA 300 , 509519 (2008)