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Following SC administration into the fatty area of the abdomen, the subcutis (the layer of skin directly below the dermis and epidermis, collectively referred to as the cutis), apomorphine is rapidly absorbed and the T max ranges from 10 to 40 min

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About 10% of tirzepatide participants had a heart-rate increase above 20 bpm during escalation, compared with 3% on placebo. A lean Japanese cohort reached +10 to +13 bpm, and 23% of Japanese participants at 15 mg crossed the abnormal-pulse threshold versus 7% of other participants, despite only 17% higher exposure. Lean and East Asian bodies showed greater cardiovascular sensitivity than exposure alone predicted

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