Chris Mertens, 35, of Menominee Falls, Wisconsin, said he had no trouble remembering to take the Wegovy pill every morning, which he did as part of a clinical trial in late 2022
Earlier research and case reports also suggest a significant rise in NAION cases among patients treated with semaglutide and tirzepatide, with some reports indicating up to a fourfold increase in risk
Its a notable shift for Medicare, which has long been barred from covering weight loss treatments
There are also the side effects like nausea, vomiting and constipation associated with the buildup of food and waste in the digestive tract
Clinical studies have shown that GLP-1 medications are highly effective for weight loss
In April 2025, a research article demonstrated how GLP-1s might drive depression and suicidal ideation in people with a genetic predisposition toward low dopamine function