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Pens are now available for several insulin preparations owing to the ease, convenience, and accuracy of drug delivery [1, 2]

Moreover, these molecular changes were accompanied by a phenotypic switch in macrophage polarization, favoring the anti-inflammatory M2 subset over the pro-inflammatory M1 phenotype (Liu et al., 2025)

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Recently, several multi-targeting agonists of GIPR, GLP-1R, or GCGR for treating T2DM and obesity have been in clinical trials