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[83] In December 2017, the injectable version with the brand name Ozempic was approved in the US for use by people with diabetes, [30] [84] and, in January 2018, in Canada

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The compound combination has made it one of the most discussed peptides in modern metabolic literature, with phase-2 readouts driving renewed interest in multi-pathway agonism

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Naltrexone/Bupropion: Nausea, constipation, headache, vomiting, and dizziness