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Beyond pancreatic -cells, GLP-1R is also found on various other cell types, such as neuronal cells, cardiovascular cells, gastrointestinal smooth muscle cells, and immune cells [10,11,12,13,14,15,16,17] (Fig

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found that acetaminophen causes concentration-dependent neuronal death in vitro at concentrations that are reached in human plasma during acetaminophen overdose, and are reached in the cerebrospinal fluid of rats for 3 h following doses that are below those required to induce acute hepatic failure in rats

& Salakhutdinov, R

doi:10.1016/s0048-9697(01)00845-2

Huang, P., Chandra, V