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[10] Additive depressant effects occur with other class I antiarrhythmics, phenytoin, and volatile anesthetics, while epinephrine-containing local formulations may potentiate vasoconstriction and delay systemic absorption-beneficial for prolonging local anesthesia but hazardous if inadvertent intravascular injection occurs

This suggested a central role for mitochondrial dysfunctioninduced senescence in AT pathogenesis, and that enhancing mitophagy was a potential therapeutic intervention (Yang et al

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Other surgical techniques include laser therapies such as HoLEP and GreenLight, which use laser energy to remove or vaporize tissue, and prostatectomyeither open or roboticwhich is typically reserved for patients with very large prostates

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The tirzepatide glycine formulation uses the same injection process