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Although initially developed for oncology, PROTAC-based strategies are now being explored in cardiovascular disease, where selective degradation of pathogenic proteins could mitigate hypertrophy, fibrosis and heart failure progression

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Nothing is known at this time about how much it will cost, or what the price will be of a competing oral agent in development that is made by Novo Nordisk

While there is mechanistic support for this (different receptor occupancy thresholds), it has not been definitively demonstrated in human studies

One article notes that DSIP levels show a diurnal variation and correlate with the bodys circadian rhythms, sleep-wake cycle and circadian rhythms

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