"Vitamin C deficiency and depletion in the United States: the Third National Health and Nutrition Examination Survey, 1988 to 1994"
A 10 , 36503658 (2022)
Again, this is all for a molecule that through FDA processes and EU processes has been deemed safe enough to be on the market for the accepted use cases
Lanifibranor, a pan-PPAR agonist, achieved MASH resolution without fibrosis worsening in 27% of patients at a 1200 mg dose, and one-stage fibrosis improvement in 26%, along with improvements in insulin sensitivity and fasting glucose levels (131)
But berberine is still a reasonable option for some people looking for gentle, natural metabolic support, and that is a different goal from prescription weight loss
DOI: 10.1097/00004850-200303000-00001 Spiering BA, Kraemer WJ, Vingren JL, et al