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Muller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, and Tschop MH
First, the treatment sequence and interaction term between the trial arm and sequence were included to account for a carryover effect of the study drug
If unsure, consulting your doctor for a B-12 level check via a blood test is advisable
The study has been approved by the institutional ethical committee (approval number: 2022/14-24) and conducted in accordance with the Declaration of Helsinki
Methylene blue is used to reduce oxidative stress, enhance mitochondrial respiration as an electron carrier, and promote the clearance of tau proteins (a group of proteins primarily found in the brain that play a critical role in maintaining the structure and function of neurons) and amyloid plaques (abnormal deposits of a protein called beta-amyloid (A) in the brain, a hallmark feature of Alzheimer's disease and other neurodegenerative conditions), which are implicated in diseases like Alzheimers, Parkinsons, and Huntingtons disease
